A New CRISPR Tool Flips Genes On and Off Like a Light Switch

A team from the University of California, San Francisco worked on gene editing tool CRISPR to observe whether its process can be reversible. Using light switches as illustration, the team began by engineering a CRISPR system, dubbed CRISPRoff, that would shut down any targeted gene without ripping the DNA. They then worked on a similar CRISPR variant that aimed to override CRISPRoff. Named CRISPRon, this tool in effect flips the genes back on – a substantial breakthrough in the field. Read full article here


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